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Because Dihydrotestosterone is incapable of interaction with the aromatase enzyme and therefore it is unable to undergo aromatization (conversion) into Estrogen, Oxandrolone shares this important trait. Its inability to aromatize into Estrogen translates into a total elimination of the potential for any and all estrogenic and Estrogen-related side effects.
Oxandrolone is alkylated at the 17th carbon atom of its steroid structure (properly known as methylation or C17-alpha alkylation) in order to bypass liver metabolism and allow it to reach the bloodstream to perform its job. Unfortunately, C17-alpha alkylation of oral anabolic steroids is known to express varying degrees of liver toxicity, but Oxandrolone has demonstrated far less in the way of liver toxicity than most other C17-alpha alkylated oral anabolic steroids. It is important, however, to still understand that Oxandrolone is not void of potential liver toxicity and that caution must still be taken in regards to its use in that respect.